Brand Name | Generic Name | Company | Treatment/Use | Sales/£m yr−1 |
---|---|---|---|---|
Losec | omeprazole | AstraZeneca | ulcers | 2490 |
Zocor | simvastatin | Merck | cholesterol lowering | 2470 |
Prozac | fluoxetine | Eli Lilley | depression | 1750 |
Norvasc | amlodipine | Pfizer | hypertension | 1600 |
Vasotec | enalapril | Merck | hypertension | 1500 |
Claritin | loratadine | Schering | antihistanmine | 1440 |
Lipitor | atorvastatin | Warner–Lambert | cholesterol lowering | 1375 |
Zoloft | sertraline | Pfizer | depression | 1150 |
Paxil | paroxetine | SmithKline Beecham | depression | 1100 |
Augmentin | amoxicillin/potassium clavulanate | SmithKline Beecham | antibiotic | 1000 |
Compound No. | R | Binding affinity/nmol l−1* | Effectiveness at reducing blood pressure in rats† |
---|---|---|---|
3 | 190 | ||
4 | 33 | ||
5 | 3.4 | ||
6 | 2.5 | ||
7 | 2.0 | ||
8 | 1.5 | ||
9 | 1.0 | ||
10 | 0.2 |