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Dr Ignacio Romero

The Open University

Ignacio Romero took his position as Lecturer in Neuroscience at the Open University in 2000.

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Articles [2]

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The Science of HIV - IntroductionBBC

By Dr Ignacio Romero (The Open University)

08 August 2006

Ignacio Romero introduces a series of articles looking at the science behind the HIV virus  Read more : The Science of HIV - Introduction

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The Origins of HIVProduction team

By Dr Ignacio Romero (The Open University)

08 August 2006

Ignacio Romero on the origins of the HIV infection in humans  Read more : The Origins of HIV

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Research [10]

Browse Dr Ignacio Romero’s latest research from Open Research Online

Watson, Christopher P.; Dogruel, Murat; Mihoreanu, Larisa; Begley, David J.; Weksler, Babette B.; Couraud, Pierre O.; Romero, Ignacio A. and Thomas, Sarah A. (2012). The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: Evidence for involvement of breast cancer resistance protein. Brain research, 1436 pp. 111–121.

Hatherell, Kathryn; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette and Pilkington, Geoffrey J. (2011). Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models. Journal of neuroscience methods, 199(2), pp. 223–229.

Shen, Weiyong; Li, Shiying; Chung, Sook Hyun; Zhu, Ling; Stayt, Jason; Su, Tao; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette and Gillies, Mark C. (2011). Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium. European Journal of Cell Biology, 90(4), pp. 323–332.

Markoutsa, Eleni; Pampalakis, Georgios; Niarakis, Anna; Romero, Ignacio A.; Weksler, Babette; Couraud, Pierre-Olivier and Antimisiaris, Sophia G. (2011). Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line. European Journal of Pharmaceutics and Biopharmaceutics, 77(2), pp. 265–274.

Georgieva, Julia V.; Kalicharan, Dharamdajal; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette; Hoekstra, Dick and Zuhorn, Inge S (2011). Surface characteristics of nanoparticles determine their intracellular fate in and processing by human blood–brain barrier endothelial cells in vitro. Molecular Therapy (In Press).

Bintig , Willem; Begandt , Daniela; Schlingmann , Barbara; Gerhard , Linda; Pangalos , Maria; Dreyer , Lutz; Hohnjec , Natalija; Couraud , Pierre-Olivier; Romero, Ignacio A; Weksler, Babette B. and Ngezahayo , Anaclet (2011). Purine receptors and Ca2+ signalling in the human blood-brain barrier endothelial cell line hCMEC/D3. Purinergic Signalling (In Press).

Mills, Jeffrey H.; Alabanza, Leah; Weksler, Babette B.; Couraud, Pierre-Olivier; Romero, Ignacio A. and Bynoe, Margaret S. (2011). Human brain endothelial cells are responsive to adenosine receptor activation. Purinergic signalling, 7(2), pp. 265–273.

Chaitanya, Ganta V.; Cromer, Walter E.; Wells, Shannon R.; Jennings, Merilyn H.; Couraud, P. Oliver; Romero, Ignacio A; Weksler, Babette; Erdreich-Epstein, Anat; Mathis, James Michael; Minagar, Alireza and Alexander, J. Steven (2011). Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro. Journal of Neuroinflammation, 8(162), (In Press).

Fletcher, Nicola F.; Wilson, Garrick K.; Murray, Jacinta; Hu, Ke; Lewis, Andrew; Reynolds, Gary M.; Stamataki, Zania; Meredith, Luke W.; Rowe, Ian A.; Luo, Guangxiang; Lopez-Ramirez, Miguel A.; Baumert, Thomas F.; Weksler, Babette; Couraud, Pierre-Olivier; Kim, Kwang Sik; Romero, Ignacio A.; Jopling, Catherine; Morgello, Susan; Balfe, Peter and McKeating, Jane A. (2011). Hepatitis C Virus infects the endothelial cells of the blood-brain barrier. Gastroenterology (In Press).

Bhattacharya, Raktima; Xu, Yan; Rahman, Md. Ashequr; Couraud, Pierre-Olivier; Romero, Ignacio A.; Weksler, Babette B.; Weidanz, Jon A. and Bickel, Ulrich (2010). A novel vascular targeting strategy for brain-derived endothelial cells using a TCR mimic antibody. Journal of Cellular Physiology, 225(3), pp. 664–672.

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Biography

Read Dr Ignacio Romero’s biography.

Ignacio Romero took his position as lecturer in neuroscience at The Open University in 2000. Since then, he has taught OU courses in biological psychology and cell and molecular biology. His research is concerned with the roles of brain cells in immune reactions, in particular how brain cells interact with white blood cells in both health and disease, an interest that stems from his doctoral research at King’s College London.

His more recent research focus, on the biology of retroviruses, emerged from his postdoctoral position at the Cochin Institute in Paris in the late 1990s, where he investigated how retroviruses such as HIV and HTLV enter the brain and cause neurological conditions. His work is carried out in vitro using culture systems designed to mimic the complex cellular environment of the human brain.

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