Dr Mark Hirst

Articles [11]

Browse all OpenLearn articles by Dr Mark Hirst

Unzip your genes - Debate the influences on characteristicsCopyrighted Image Jupiter Images

By Dr Rosa Hoekstra (The Open University), Dr Mark Hirst (The Open University)

24 March 2011

Join the discussion: So there are genetic and environmental influences on our characteristics. But is it really that simple? Perhaps our genes can... Read more : Unzip your genes - Debate the influences on characteristics

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Unzip your genes - Debate missing heritabilityCopyrighted Image Jupiter Images

By Dr Rosa Hoekstra (The Open University), Dr Mark Hirst (The Open University)

24 March 2011

Join the discussion: What is 'missing heritability'? Read more : Unzip your genes - Debate missing heritability

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Unzip your genes - Debate specific gene disordersCopyrighted Image Jupiter Images

By Dr Rosa Hoekstra (The Open University), Dr Mark Hirst (The Open University)

24 March 2011

Join the discussion: Is there a 'gene for autism', or an 'obesity gene'? Read more : Unzip your genes - Debate specific gene disorders

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Unzip your genes - Debate the gap in our understandingCopyrighted Image Jupiter Images

By Dr Rosa Hoekstra (The Open University), Dr Mark Hirst (The Open University)

24 March 2011

Join the discussion: What might be the explanation for 'missing heritability'? What explains this gap in our understanding? Read more : Unzip your genes - Debate the gap in our understanding

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Unzip your genes - Debate the genetic influence on body weightCopyrighted Image Jupiter Images

By Dr Rosa Hoekstra (The Open University), Dr Mark Hirst (The Open University)

24 March 2011

Join the discussion: How do we know that genes influence how much weight we gain, surely people differ in how much food they eat and... Read more : Unzip your genes - Debate the genetic influence on body weight

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Unzip your genes Featuring: activity, The Open University

By Dr Rosa Hoekstra (The Open University), Dr Mark Hirst (The Open University), The OpenLearn team (The Open University)

24 March 2011

Try this quiz to determine whether common traits are hereditary or influenced by the environment Read more : Unzip your genes

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Unzip your genes - Debate the value of twin studiesCopyrighted Image Jupiter Images

By Dr Rosa Hoekstra (The Open University), Dr Mark Hirst (The Open University)

24 March 2011

Join the discussion: Do we really know that the values obtained from twin studies are correct? Are twins different from singletons? Do identical and... Read more : Unzip your genes - Debate the value of twin studies

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Unzip your genes - Debate being a victim of your genesCopyrighted Image Jupiter Images

By Dr Rosa Hoekstra (The Open University), Dr Mark Hirst (The Open University)

24 March 2011

Join the discussion: If something is found to be highly heritable, does this mean I can't do anything about it? Am I simply a victim... Read more : Unzip your genes - Debate being a victim of your genes

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All about chromosomesThinkstock

By Dr Mark Hirst (The Open University)

10 February 2011

Did you know that humans have more chromosomes per cell than a pig, but less than a chicken? Explore the fascinating world of chromosomes and... Read more : All about chromosomes

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There's a mammoth in my freezerNo Copyright Image Woudlooper

By Dr Mark Hirst (The Open University)

30 November 2008

Mark Hirst looks behind the headline at the possibility of creating life from frozen animal remains. Read more : There's a mammoth in my freezer

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Research [8]

Browse Dr Mark Hirst’s latest research from Open Research Online

Dallerac, G. M.; Vatsavayai, S. C.; Cummings, D. M.; Milnerwood, A. J.; Peddie, C. J.; Evans, K. A.; Walters, S. W.; Rezaie, P.; Hirst, M. C. and Murphy, K. P. S. J. (2011). Impaired long-term potentiation in the prefrontal cortex of Huntington's disease mouse models: rescue by D(1) dopamine receptor activation. Neurodegenerative Diseases, 8(2),

Cummings, Damian M.; Milnerwood, Austen J.; Dallerac, Glenn M.; Vatsavayai, Sarat C.; Hirst, Mark C. and Murphy, Kerry P. S. J. (2007). Abnormal cortical synaptic plasticity in mice transgenic for exon 1 of the human Huntington's protein. Brain Research Bulletin, 72(2-3), pp. 103–107.

Vatsavayai, Sarat C.; Dallerac, Glenn M.; Milnerwood, Austen J.; Cummings, Damian M.; Rezaie, Payam; Murphy, Kerry P.S.J. and Hirst, Mark C. (2007). Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset. Brain Research Bulletin, 72(2-3), pp. 98–102.

Cummings, Damian M.; Milnerwood, Austen J.; Dallerac, Glenn M.; Waights, Verina; Brown, Jacki Y.; Vatsavayai, Sarat C.; Hirst, Mark C. and Murphy, Kerry P. S. J. (2006). Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of huntington's disease. Human Molecular Genetics, 15(19), pp. 2856–2868.

Milnerwood, Austen J.; Cummings, Damian M.; Dallerac, Glenn M.; Brown, Jacki Y.; Vatsavayai, Sarat C.; Hirst, Mark C.; Rezaie, Payam and Murphy, Kerry P.S.J. (2006). Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease. Human Molecular Genetics, 15(10), pp. 1690–1703.

Chandler, Simon P.; Kansagra, Pushpa and Hirst, Mark C. (2003). Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. BMC Molecular Biology, 4(3),

Hirst, Mark C. and Fisch, Gene S. (2003). The Fragile X Syndrome and the Fragile X Mutation. In: Fisch, Gene S. ed. Genetics and Genomics of Neurobehavioral Disorders. Contemporary Clinical Nueroscience. USA: Humana Press, pp. 335–390.

Bontekoe, C.J.M.; Bakker, C.E.; Nieuwenhuizen, I.M.; van der Linde, H.; Lans, H.; de Lange, D; Hirst, M.C. and Oostra, B.A. (2001). Instability of a (CGG)(98) repeat in the Fmr1 promoter. Human Molecular Genetics, 10(16), pp. 1693–1699.

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Comments [22]

Read what people are saying about Dr Mark Hirst’s OpenLearn articles

There's a mammoth in my freezer

Comment posted by zz910637

17 Apr 2012

I like this website shown and it has given me some sort of inspiration to succeed for some reason, so thanks. Multidecks Read more : There's a mammoth in my freezer

Unzip your genes - Debate the value of twin studies

Comment posted by om2245

30 Aug 2011

Hi Paul, The programme I think you are looking for was called The Secret Life of Twins - http://www.bbc.co.uk/programmes/b00n6yyz. It wasn't an Open University programme but someone here remembered... Read more : Unzip your genes - Debate the value of twin studies

Unzip your genes - Debate the value of twin studies

Comment posted by zz821424

29 Aug 2011

Hi I was watching a documentary on T.V a couple of nights ago (can't remember what side or what it was called now) but anyway it was going on about how new research that is being carried out showing... Read more : Unzip your genes - Debate the value of twin studies

Unzip your genes - Debate the value of twin studies

Comment posted by sk5654

27 Aug 2011

Dear Dr Hoekstra, You posted : but life style factors and food intake may also be important Yes no doubt. However given the same house hold you could not say that both food intake and life style... Read more : Unzip your genes - Debate the value of twin studies

Unzip your genes - Debate the value of twin studies

Comment posted by zz815711

18 Aug 2011

Very interesting. I am a 60 year old identical twin; my twin, who remains pretty similar to me is living and working in Australia. We have extremely similar interests (both have flown and photograph... Read more : Unzip your genes - Debate the value of twin studies

Unzip your genes - Debate the influences on characteristics

Comment posted by zz785720

10 Jun 2011

This is a subject that is of great interest to me, though I should declare that I am neither a qualified life scientist, nor a formal student of life sciences. I used to engage with the old Open2... Read more : Unzip your genes - Debate the influences on characteristics

Unzip your genes - Debate the value of twin studies

Comment posted by zz784008

05 Jun 2011

I am very intrigued by information like this. I even took the quiz about what behaviors are thought to be heritable and what research on twin studies shows. Now perhaps I misunderstood or maybe I... Read more : Unzip your genes - Debate the value of twin studies

Unzip your genes - Debate the value of twin studies

Comment posted by zz784008

05 Jun 2011

I am very intrigued by information like this. I even took the quiz about what behaviors are thought to be heritable and what research on twin studies shows. Now perhaps I misunderstood or maybe I... Read more : Unzip your genes - Debate the value of twin studies

Unzip your genes

Comment posted by om2245

16 May 2011

Hi Simon - many thanks for this, our tecnical team are investigating. OpenLearn Moderator Read more : Unzip your genes

Unzip your genes

Comment posted by zz777455

14 May 2011

Great fun - we've covered this over at Genome Engineering http://www.genome-engineering.com/unzip-your-genes.html Read more : Unzip your genes

Biography

Read Dr Mark Hirst’s biography.

Dr Mark Hirst is a senior lecturer in human genetics at The Open University. He's been working in molecular biology for over 25 years, focussing on genetics of human neurological diseases, especially those that involve DNA synthesis, damage and repair.

Articles [11]

Browse all OpenLearn articles by Dr Mark Hirst

Unzip your genes - Debate the influences on characteristicsCopyrighted Image Jupiter Images

Unzip your genes - Debate missing heritabilityCopyrighted Image Jupiter Images

Unzip your genes - Debate specific gene disordersCopyrighted Image Jupiter Images

Unzip your genes - Debate the gap in our understandingCopyrighted Image Jupiter Images

Unzip your genes - Debate the genetic influence on body weightCopyrighted Image Jupiter Images

Unzip your genes Featuring: activity, The Open University

Unzip your genes - Debate the value of twin studiesCopyrighted Image Jupiter Images

Unzip your genes - Debate being a victim of your genesCopyrighted Image Jupiter Images

All about chromosomesThinkstock

There's a mammoth in my freezerNo Copyright Image Woudlooper

Research [8]

Browse Dr Mark Hirst’s latest research from Open Research Online

Ratings [0]

Browse all OpenLearn articles rated by Dr Mark Hirst

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Comments [22]

Read what people are saying about Dr Mark Hirst’s OpenLearn articles

Biography

Read Dr Mark Hirst’s biography.

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