Nucleic acids and chromatin
Nucleic acids and chromatin

This free course is available to start right now. Review the full course description and key learning outcomes and create an account and enrol if you want a free statement of participation.

Free course

Nucleic acids and chromatin

2.2 General features of higher-order nucleic acid structure

Polynucleotide chains are intrinsically flexible molecules and have the potential to form many different higher-order structures. Their flexibility derives from rotation around bonds in the sugar-phosphate backbone (Figure 3b). In vivo, the structures that form are obviously determined by both the proteins that synthesise the nucleic acid chains (polymerases) and the ancillary proteins that bind to and modify them. We will discuss these aspects of structure later in this unit. What drives the formation of these structures are the properties of the component nucleotides and the interactions between them in the form of base pairing and base stacking.


For further information, take a look at our frequently asked questions which may give you the support you need.

Have a question?
Free Courses

OpenLearn has over 800 free courses across all our subjects designed by our academic experts. From 1 to 100 hours, introductory to advanced, you can start learning at any time and all for free.