Nucleic acids and chromatin
Nucleic acids and chromatin

This free course is available to start right now. Review the full course description and key learning outcomes and create an account and enrol if you want a free statement of participation.

Free course

Nucleic acids and chromatin

Summary of Section 6

  1. Sequence-specific protein–DNA interactions are achieved through the formation of non-covalent bonds between amino acid side-chains in the protein and bases in the major groove of the DNA.

  2. Non-sequence-specific protein–DNA interactions are achieved primarily through electrostatic interactions between positively charged amino acid side-chains and the negatively charged DNA backbone.

  3. Protein and DNA conformation can be altered after binding, which can enhance further binding of proteins through cooperativity, or cause structural alterations to the DNA helix.

S377_1

For further information, take a look at our frequently asked questions which may give you the support you need.

Have a question?
Free Courses

OpenLearn has over 800 free courses across all our subjects designed by our academic experts. From 1 to 100 hours, introductory to advanced, you can start learning at any time and all for free.