Nucleic acids and chromatin
Nucleic acids and chromatin

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Nucleic acids and chromatin

Summary of Section 6

  1. Sequence-specific protein–DNA interactions are achieved through the formation of non-covalent bonds between amino acid side-chains in the protein and bases in the major groove of the DNA.

  2. Non-sequence-specific protein–DNA interactions are achieved primarily through electrostatic interactions between positively charged amino acid side-chains and the negatively charged DNA backbone.

  3. Protein and DNA conformation can be altered after binding, which can enhance further binding of proteins through cooperativity, or cause structural alterations to the DNA helix.

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