Summary of Section 8
Eukaryotic DNA is compacted through a hierarchical series of events, from nucleosomes to 10nm and 30 nm fibres, then through further stages to the chromomena fibres, which are attached to scaffolds to form loops. In preparation for mitosis, these fibres are further compacted to prevent physical damage.
Chromosomes within the interphase nucleus occupy defined regions.
DNA within the eukaryotic interphase nucleus is in a dynamic and variable state. Scaffolds to which the DNA fibres are attached serve both structural roles in further compaction and as delineators of gene domains.