from The Open University
Alternatively you can skip the navigation by pressing 'Enter'.
The Bottom Line - Corporate scandalSaturday, 28th March 2015 17:30 - BBC Radio 4How do companies recover from negative press? Evan Davis hears from guests who have broken away from scandal on this... Read more: The Bottom Line - Corporate scandal
Wartime Farm: ChristmasSunday, 29th March 2015 08:00 - Yesterday
Timewatch: StonehengeSunday, 29th March 2015 22:05 - BBC Four
Thinking Allowed: Global clothing and poverty, fur inheritance in PolandMonday, 30th March 2015 00:15 - BBC Radio 4
Timewatch: StonehengeAvailable until Thursday, 23rd April 2015 12:30Two of Britain’s leading archaeologists and world-renowned experts on Stonehenge, Professor Tim Darvill and Geoff... Read more: OU on the BBC: Timewatch - Stonehenge
The Bottom Line - Corporate scandalAvailable until Saturday, 26th March 2016 14:00
Timewatch: StonehengeAvailable until Friday, 24th April 2015 12:30
Thinking Allowed: Global clothing and poverty, fur inheritance in PolandAvailable until Monday, 20th April 2015 08:30
Turn your bank holiday into a badged holidayWhat are your plans for the long weekend? DIY? A trip to a windswept beach? Why not take your... Read more: Turn your bank holiday into a badged holiday
Take the photographic memory testCan you capture scenes just by looking at them? Find out with our photographic memory test. Launch now: Take the photographic memory test
Early years team work and leadershipThis unit explores aspects of teamwork and leadership for early years practitioners. Try: Early years team work and leadership now
Succeed with maths – Part 1[BETA] If you feel that maths is a mystery that you want to unravel then this short 8-week course... Try: Succeed with maths – Part 1 now
Pain and Aspirin
What causes pain and how do we stop it? This unit looks at how the human body responds...
What causes pain and how do we stop it? This unit looks at how the human body responds to the release of certain chemicals and as a result feels pain. Pain can be reduced by inhibiting the formation of such chemicals and you will learn how the molecular structure of aspirin has been formulated to help in this process.
By the end of this unit you should have achieved the following learning outcomes.
- demonstrate general knowledge and understanding of some of the basic facts, concepts and principles relating to the development of medicines. In particular:
- the science behind the development of some drugs to achieve particular tasks;
- how chemical bonding determines the properties of compounds and provides an explanation for the mode of action of drugs.
- apply this knowledge and understanding to address familiar and unfamiliar situations;
- be able to express unit concepts in an objective and factually correct way.
- receive and respond to information obtained from text and models, as well as from numeric, pictorial and audio sources;
- communicate information clearly, concisely and correctly.
- (if you obtain a model kit) construct and manipulate models of molecules.
- Current section: Introduction
- Learning outcomes
- 1 Ouch – that hurts!
- 1.1 Why does it hurt?
- 1.2 How does it hurt?
- 1.3 The aspirin story
- 1.4 The molecules involved
- 1.5 Some chemistry involving esters
- 1.6 How does aspirin relieve pain?
- 1.7 Enzymes
- 1.8 Enter aspirin!
- 9 Summary
- Next steps
Pain and aspirin
In this unit you will find out that the sensation of pain is caused by the release of a chemical called prostaglandin that stimulates the nerve endings and sends an electrical message to the brain. Inhibiting the formation of prostaglandin reduces pain and we will see, by looking at the specific shape of the molecules involved, how aspirin can so inhibit the formation of prostaglandin. To make the most of the material of this unit you will need to use an organic molecular modelling kit such as the one that is supplied by Molymod™ to Open University students who study the course that this unit comes from.
This unit is an adapted extract from the Open University course Learn about molecules, medicines and drugs which has been partly funded by the Wolfson Foundation in collaboration with The Royal Society of Chemistry and you can study for credit., or