(Description) Figure 5 The protein structure of PBP2a. The figure shows a ribbon diagram of the PBP2a protein structure. The ribbon shows the overall organisation of the protein giving a representation of the overall protein shape. The ß-lactam binding site (indicated with an arrow) is inaccessible to ß-lactam antibiotics because of changes to the structure of PBP2a (see Figure 2 in Section 1.1) (Lim and Strynadka, 2002). You do not need to study this structure in detail.

Week 3: How do bacteria become resistant to antibiotics?

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This figure shows a picture of the protein structure of PBP2a. This structure is comprised of beta structures shown in yellow, alpha helices shown in pink and loop regions shown in white. The binding site for β-lactam antibiotics is indicated with an arrow.

3.2.1 PBP2a – a PBP that doesn’t bind cephalosporins