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Introduction to histopathology

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Figure 12 Protein aggregates in brain cells associated with human degenerative diseases. Arrows highlight (a) extracellular plaques in prion disease, (b) extracellular plaques (blue) and neurofibrillary tangles (yellow) in Alzheimer's disease, (c) nuclear aggregates in Huntington's disease, (d) cytosolic aggregates known as 'Lewy bodies' in Parkinson's disease, (e) nuclear aggregates in amyotrophic lateral sclerosis and (f) accumulations of sphingolipids in the distended neurons of a patient with Niemann-Pick disease.

 3.3 Degenerative diseases and storage disorders