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Intracellular transport

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Figure 8 A model of intermediate filament assembly.(a) A monomer with an α-helical region. (b) Two monomers pair up to form a coiled-coil dimer. (c) Two dimers then align side-to-side to form an antiparallel tetramer of four polypeptide chains, slightly offset from each other, which allows (d) alignment with another tetramer. (e) In the final rope-like filament, tetramers are packed together in a helical array. An electron micrograph of intermediate filaments is shown upper left.

 1.4 Specialised intermediate filaments