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# Long description

The diagram shows a membrane-spanning integrin molecule, the extracellular part of which is bound to a fibronectin molecule in the extracellular matrix. The fibronectin is also bound to a collagen molecule, and thus acts as molecular bridge between the integrin and the collagen. The cytosolic part of the integrin molecule is similarly bound via a protein linker molecule to an actin filament of the cytoskeleton.