Long description
The diagram shows a membrane-spanning integrin molecule, the extracellular part of which is bound to a fibronectin molecule in the extracellular matrix. The fibronectin is also bound to a collagen molecule, and thus acts as molecular bridge between the integrin and the collagen. The cytosolic part of the integrin molecule is similarly bound via a protein linker molecule to an actin filament of the cytoskeleton.