4.2.1 Influencing the curve

A number of biological factors influence the oxygen–haemoglobin dissociation curve and shift it to the right or left. These factors are summarised in the following video.

The term ‘affinity’ refers to the strength of binding between two particles or proteins. Low affinity means that the binding is weak and the particles can be easily separated. High affinity means that the binding is strong. In the context of Hb and O2, low affinity means that the O2 binds weakly to the Hb and is therefore easily transferred to the tissues.

Video 11 Factors influencing the oxygen–haemoglobin dissociation curve.
Transcript (opens in new window)

Question 9 Biological factors

Having watched Video 11, note down the biological factors that affect the affinity of Hb binding of O2.

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Answer

  • CO2
  • acidity
  • 2,3-DPG
  • exercise
  • temperature

OpenLearn - Blood and the respiratory system
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