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Cell signalling
Cell signalling

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3.4.3 Cyclic GMP

Cyclic GMP (cGMP) is a second messenger with many similarities to cAMP. It is synthesized from GTP by guanylyl cyclase, and degraded to 5´- GMP by cyclic GMP phosphodiesterases. Some of the targets of cGMP are analogous to those of cAMP: cGMP-dependent protein kinase (PKG), and cGMP-gated Na+ ion channels.

  • We have already discussed a type of receptor that employs cGMP for signal transfer. What type of receptor is it?

  • Receptors with intrinsic enzymatic activity with an intracellular guanylyl cyclase catalytic domain (Figure 23a).