Metals in medicine
Skip contents

Contents

  • Introduction
  • Learning outcomes
  • 1 Imaging in medicine
  • 2 Anatomical imaging using X-rays
    • 2.1 Computed tomography (CT) scans
    • 2.2 X-ray contrast agents
      • Barium sulfate
      • Other X-ray contrast agents
  • 3 Anatomical imaging using MRI
    • 3.1 MRI in practice
    • 3.2 MRI: theoretical background
    • 3.3 MRI: Producing an image
      • Spatial localisation
    • 3.4 Contrast in MRI
      • Relaxation time
      • T1- and T2-weighted images
    • 3.5 Chemistry of the lanthanides
      • Ionic radii of the lanthanides
      • Paramagnetism of lanthanide complexes
    • 3.6 MRI contrast agents
      • Gadolinium complexes
  • 4 Metals for therapeutic applications
    • 4.1 Brief historical background
    • 4.2 Current use of metals in medicine: an overview
  • 5 Cancer therapy: the cisplatin story
    • 5.1 Aquation of cisplatin
    • 5.2 Biological targets of cisplatin
    • 5.3 Platinum binding to DNA
      • The 1,2-intrastrand cross-links
    • 5.4 Anticancer effect
    • 5.5 Why is transplatin inactive?
    • 5.6 Cisplatin in the body
    • 5.7 Side effects of cisplatin
    • 5.8 Resistance to cisplatin
    • 5.9 Limitations of cisplatin
  • Conclusion
  • Acknowledgements

ou logoCreative Commons non-commercial share alike icon Except for third party materials and otherwise stated in the acknowledgements section, this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Licence

Please see full copyright statement and terms of use for more details.