5.9 Limitations of cisplatin
Now watch the following video which summarises the limitations of cisplatin from a chemical viewpoint and looks at strategies for the development of new drugs. It starts by mentioning the drug carboplatin.
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What aspect of the chemistry of the cisplatin molecule motivated the search for alternative platinum-based drugs?
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The reactivity of the molecule – in particular, the rate at which chloride ligands leave the complex.
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What are combinatorial methods?
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A synthetic approach designed to produce a large number of related compounds in a single process – in this case, different combinations or permutations of ligands. The video referred to the technique as ‘one-pot cooking’.
OpenLearn - Metals in medicine
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