5.3.2 Conclusion after reading this article:
The paper suggests that the factors that had long been considered responsible for neurodegenerative disease are also important for normal neuronal function. For example, they exert a physiological homeostatic effect by reducing excitatory transmission in response to neuronal activity. Aβ peptide is no longer considered the masked villain in the brain, particularly of elderly people. Providing the concentration of Aβ is maintained within set physiological limits in the brain it, has a clear beneficial role for neuronal function – outside these limits, then the accumulation of Aβ can have profound and devastating consequences for brain function.