Glossary


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A

antimicrobial susceptibility testing (AST)

The determination of the susceptibility of a bacterial isolate to antimicrobials designed to kill or inhibit it.


antimicrobial use (AMU)

The quantity of antimicrobial drugs prescribed or administered to an individual person or animal, or group of animals (e.g. herd, flock), measured at the level of healthcare facility, farm, region or country.


B

bacterial isolate

A pure culture of a bacterial strain isolated from a mixed population of bacteria in an animal/human or environment. In the context of AMR surveillance this will be a strain we are interested in because we want to know if it is resistant to one or more antimicrobials.


bias

Errors that represent a consistent deviation from the true value – for example, measurements that are consistently higher or lower than the true value. It can arise due to problems with the design, data collection, data management or analysis stages of surveillance, or research studies.


C

census

Collecting data from every single unit (e.g. human, animal, farm) of a population or category of objects.


commensal bacteria

Bacteria that normally live in or on the human or animal body without causing disease. In fact, some of these are beneficial to the host in different ways, which includes competing with other potentially pathogenic bacteria.


confidence level

The probability of getting the results observed by chance alone: the higher the confidence, the less likely the results observed are due to chance. Larger sample sizes result in higher levels of confidence. Confidence levels of 90% or 95% are commonly used.


D

defined daily dose

A statistical measure of drug consumption, defined by the World Health Organization Collaborating Centre for Drug Statistics Methodology.


dropout rate

The loss of collected samples due to issues with sample transport, failure to obtain a result from the sample analysis in the laboratory, etc. Sample size calculations should take this into consideration.


E

error

Deviation from the true value that occurs due to chance alone. In general, the smaller the sample size, the larger the random error.


error (random)

Deviation from the true value that occurs due to chance alone. In general, the smaller the sample size, the larger the random error.


external validity

The degree to which the sample is representative of the target population. It is required to extrapolate findings from the sampled population to the target population. It is sometimes referred to as ‘generalisability’.


I

internal validity

The degree to which the sample is representative of the source population.


M

multidrug-resistant

Bacteria (or, infrequently, other micro-organisms) that are resistant to a range of different antibiotics.


P

power

The power of a study is the probability of detecting an effect, such as a difference between two groups, if it is true. Larger sample sizes result in more power. In general, powers of 80% or higher are considered acceptable.


precision

In the context of sample size calculations, precision describes the margin of random error around an estimate. Precisions of 5% or lower are commonly used.


prevalence

The proportion of a population with a particular condition at a particular time, such as the number of Salmonella isolates in the population that are resistant to a particular antibiotic at the time of reading.


probability

The extent to which an event is likely to occur, expressed quantitatively as a value between 0 and 1 (or between 0% and 100%).


S

sample

Single units from a category (e.g. human, animal, farm) selected to be representative of the category as a whole.


sampling frame

A list of all sampling units in the source population.


sampling unit

The basic element(s) of the population we are sampling. This is often the case when sampling is conducted in multiple steps, or stages. For example, we may have: 

  • farms (primary sampling unit) 
  • pens or sheds (secondary sampling unit) 
  • individual animals (tertiary sampling unit).

source (study) population

The actual population from which eligible study subjects are drawn, such as commercial broiler farms in selected provinces. Ideally, the source population should be the same as the target (reference) population, but this is often not practical.


study sample

The units selected from the source population; for example, 200 birds from five flocks on ten farms.


T

target (reference) population

The population to which the results will be extrapolated to; for example, all commercial broiler farms in a country.


Z

zoonotic bacteria

Disease-causing bacteria that can be transferred from animals to people.



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