1.3 Types of antibiotic

Antibiotics may be active against a wide range of bacteria (broad-spectrum) or just a few types (narrow-spectrum). Additionally, antibiotics either kill bacterial cells (bactericidal) or stop them growing and dividing (bacteriostatic).

Factors that determine the spectrum of antibiotic activity include:

  • ability to penetrate the bacterial cell – since most bacterial targets are located in the cell’s interior
  • how widespread the target is among different bacterial species
  • bacterial resistance to the antibiotic.

1.2 Potential bacterial targets for antibiotics

1.3.1 Gram-positive and Gram-negative bacteria