4.1 The origin of CTX-M-type ESBLs
Unlike most acquired β-lactamases, for which the source remains unknown, the source of CTX-M-type ESBLs has been identified as members of the bacterial
The resistance of Kluyvera spp. to third generation cephalosporins is an example of what type of resistance?
It is an example of intrinsic resistance.
These chromosomal CTX-M precursor genes have been captured and incorporated into plasmids
In the next section, you will look at how these plasmid-encoded CTX-M genes have been rapidly spread by horizontal gene transfer to other bacterial types, including E. coli and Klebsiella pneumoniae.