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...changes that are not inherited from either parent, so-called de novo mutations, can also play a role in the development of autism. Researchers think that these de novo gene variants may play a more prominent role in those families where just one person has autism (also called sporadic autism). The occurrence of new genetic changes, not inherited from either parent, could...

...change, the British cyclist Chris Boardman set a new record using modern equipment, riding slightly more than 56 km in the one-hour period. This is now called the ‘best human effort’ record by the UCI. Then later he set it again under the new rules using 1970s equipment, this time riding only slightly more than 49 km. The difference in technology can be seen in the...

...change. Some people wish to plan in advance in case of accidents or other unpredictable life events – so advance care planning is not just for those who know they are likely to die soon. For those who do advance care planning, it can be life-affirming and provide them a sense of independence and control over situations. An advance care plan that covers preferences is...

...change. It is important to recognise that life can feel chaotic and unpredictable; many situations do not have a clear right or wrong solution. However, Acceptance and Commitment Therapy (ACT) can help us to become unstuck from unhelpful thoughts and feelings, and take action towards the lives we really want, despite uncertainty and setbacks. ACT Acceptance and Commitment...