Science, Maths & Technology
Cell signalling
...projecting into the cytosol. Carbon atoms 3, 4 and 5 of the inositol ring can be phosphorylated by lipid kinases (Figure 30). The best-studied enzymes employing these substrates are the phospholipase C family, which cleave the fatty acyl chains from the inositol ring, and phosphatidylinositol 3-kinase (PI 3-kinase), which phosphorylates carbon atom 3 of the inositol ring....