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Histology, microscopy, anatomy and disease
Histology, microscopy, anatomy and disease

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1.4 Infection

This activity will show you examples of diseases that affect tissues with which you are familiar. In each case the normal tissue section is included (Slides 2 and 4), so that you can compare normal and diseased tissue more easily. You should use the legends to navigate around the sections.

Activity 2

Open the virtual microscope [Tip: hold Ctrl and click a link to open it in a new tab. (Hide tip)] in a new window or tab. Find Slides 1–4 in the ‘Week 4’ category.

Look at Slides 1 and 2. They are sections of lung. Slide 1 is from a patient with miliary tuberculosis, which resulted from an infection with the bacterium mycobacterium tuberculosis. Notice how the bacteria have produced cell death (necrosis) in the centre of the tubercle, and the distinctive appearance of the chronic inflammatory reaction surrounding it.

Look at Slides 3 and 4. They are sections of kidney. Slide 3 is from a patient who had chronic inflammation caused by a bacterial infection (Staphylococcus aureus). The bacteria are not visible with the H&E stain, but notice the infiltration of the kidney cortex by large numbers of leukocytes (macrophages, neutrophils and lymphocytes).